using Python.Runtime;

    Environment.SetEnvironmentVariable("PATH", Path.GetFullPath(@"C:\\Users\\admin\\anaconda3\\envs\\pm3env"), EnvironmentVariableTarget.Process);
    PythonEngine.PythonHome = "C:\\Users\\admin\\anaconda3\\envs\\pm3env";
    using (Py.GIL())
    {
        // dynamic np = Py.Import("numpy");
        // Console.WriteLine(np.cos(np.pi * 2));
    
        dynamic os = Py.Import("os");
        Console.WriteLine(os.listdir());
    
    }
    PythonEngine.BeginAllowThreads();
    Console.WriteLine("press Ctrl+C to quit");
    Console.ReadKey();

    using Python.Runtime;

    Environment.SetEnvironmentVariable("PATH", Path.GetFullPath(@"C:\\Users\\admin\\anaconda3\\envs\\pm3env"), EnvironmentVariableTarget.Process);
    PythonEngine.PythonHome = "C:\\Users\\admin\\anaconda3\\envs\\pm3env";
    using (Py.GIL())
    {
        dynamic np = Py.Import("numpy");
        Console.WriteLine(np.cos(np.pi * 2));
    }
    PythonEngine.BeginAllowThreads();
    Console.WriteLine("press Ctrl+C to quit");
    Console.ReadKey();