diff --git a/.github/workflows/libclang-python-tests.yml b/.github/workflows/libclang-python-tests.yml
index 50ef4acf2feb1..43b50cec61716 100644
--- a/.github/workflows/libclang-python-tests.yml
+++ b/.github/workflows/libclang-python-tests.yml
@@ -10,15 +10,15 @@ on:
       - 'main'
     paths:
       - 'clang/bindings/python/**'
+      - 'clang/test/bindings/python/**'
       - 'clang/tools/libclang/**'
-      - 'clang/CMakeList.txt'
       - '.github/workflows/libclang-python-tests.yml'
       - '.github/workflows/llvm-project-tests.yml'
   pull_request:
     paths:
       - 'clang/bindings/python/**'
+      - 'clang/test/bindings/python/**'
       - 'clang/tools/libclang/**'
-      - 'clang/CMakeList.txt'
       - '.github/workflows/libclang-python-tests.yml'
       - '.github/workflows/llvm-project-tests.yml'
 
diff --git a/clang/CMakeLists.txt b/clang/CMakeLists.txt
index 94607a8e8473c..72386132bce9f 100644
--- a/clang/CMakeLists.txt
+++ b/clang/CMakeLists.txt
@@ -530,7 +530,6 @@ if( CLANG_INCLUDE_TESTS )
     clang_unit_site_config=${CMAKE_CURRENT_BINARY_DIR}/test/Unit/lit.site.cfg
   )
   add_subdirectory(test)
-  add_subdirectory(bindings/python/tests)
 
   if(CLANG_BUILT_STANDALONE)
     umbrella_lit_testsuite_end(check-all)
diff --git a/clang/bindings/python/tests/CMakeLists.txt b/clang/bindings/python/tests/CMakeLists.txt
deleted file mode 100644
index a0ddabc21bb41..0000000000000
--- a/clang/bindings/python/tests/CMakeLists.txt
+++ /dev/null
@@ -1,66 +0,0 @@
-# Test target to run Python test suite from main build.
-
-# Avoid configurations including '-include' from interfering with
-# our tests by setting CLANG_NO_DEFAULT_CONFIG.
-add_custom_target(check-clang-python
-    COMMAND ${CMAKE_COMMAND} -E env
-            CLANG_NO_DEFAULT_CONFIG=1
-            CLANG_LIBRARY_PATH=$<TARGET_FILE_DIR:libclang>
-            "${Python3_EXECUTABLE}" -m unittest discover
-    DEPENDS libclang
-    WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/..)
-
-set(RUN_PYTHON_TESTS TRUE)
-set_target_properties(check-clang-python PROPERTIES FOLDER "Clang/Tests")
-
-# Tests require libclang.so which is only built with LLVM_ENABLE_PIC=ON
-if(NOT LLVM_ENABLE_PIC)
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-# Do not try to run if libclang was built with sanitizers because
-# the sanitizer library will likely be loaded too late to perform
-# interception and will then fail.
-# We could use LD_PRELOAD/DYLD_INSERT_LIBRARIES but this isn't
-# portable so its easier just to not run the tests when building
-# with ASan.
-if(NOT LLVM_USE_SANITIZER STREQUAL "")
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-# Tests fail on Windows, and need someone knowledgeable to fix.
-# It's not clear whether it's a test or a valid binding problem.
-if(WIN32)
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-# The Python FFI interface is broken on AIX: https://bugs.python.org/issue38628.
-if(${CMAKE_SYSTEM_NAME} MATCHES "AIX")
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-# AArch64, Hexagon, and Sparc have known test failures that need to be
-# addressed.
-# SystemZ has broken Python/FFI interface:
-# https://reviews.llvm.org/D52840#1265716
-if(${LLVM_NATIVE_ARCH} MATCHES "^(AArch64|Hexagon|Sparc|SystemZ)$")
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-# Tests will fail if cross-compiling for a different target, as tests will try
-# to use the host Python3_EXECUTABLE and make FFI calls to functions in target
-# libraries.
-if(CMAKE_CROSSCOMPILING)
-  # FIXME: Consider a solution that allows better control over these tests in
-  # a crosscompiling scenario. e.g. registering them with lit to allow them to
-  # be explicitly skipped via appropriate LIT_ARGS, or adding a mechanism to
-  # allow specifying a python interpreter compiled for the target that could
-  # be executed using qemu-user.
-  message(WARNING "check-clang-python not added to check-all as these tests fail in a cross-build setup")
-  set(RUN_PYTHON_TESTS FALSE)
-endif()
-
-if(RUN_PYTHON_TESTS)
-    set_property(GLOBAL APPEND PROPERTY
-                 LLVM_ALL_ADDITIONAL_TEST_TARGETS check-clang-python)
-endif()
diff --git a/clang/test/CMakeLists.txt b/clang/test/CMakeLists.txt
index e5b4a3bb84645..a9b88d4f4d9ec 100644
--- a/clang/test/CMakeLists.txt
+++ b/clang/test/CMakeLists.txt
@@ -205,6 +205,17 @@ add_custom_target(clang-test)
 add_dependencies(clang-test check-clang)
 set_target_properties(clang-test PROPERTIES FOLDER "Clang/Tests")
 
+# Allow running Clang Python binding tests separately from CI.
+add_lit_testsuite(check-clang-python "Running the Clang Python tests"
+  ${CMAKE_CURRENT_BINARY_DIR}
+  #LIT ${LLVM_LIT}
+  PARAMS ${CLANG_TEST_PARAMS}
+  DEPENDS ${CLANG_TEST_DEPS}
+  ARGS ${CLANG_TEST_EXTRA_ARGS} --filter=bindings.sh
+  # Avoid running tests twice.
+  EXCLUDE_FROM_CHECK_ALL
+  )
+
 # FIXME: This logic can be removed once all buildbots have moved
 # debuginfo-test from clang/test to llvm/projects or monorepo.
 if(EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/debuginfo-tests)
diff --git a/clang/test/bindings/python/bindings.sh b/clang/test/bindings/python/bindings.sh
new file mode 100755
index 0000000000000..3f7a51ef9ca49
--- /dev/null
+++ b/clang/test/bindings/python/bindings.sh
@@ -0,0 +1,38 @@
+#!/bin/sh
+
+# UNSUPPORTED: !libclang-loadable
+
+# Tests fail on Windows, and need someone knowledgeable to fix.
+# It's not clear whether it's a test or a valid binding problem.
+# XFAIL: target={{.*windows.*}}
+
+# The Python FFI interface is broken on AIX: https://bugs.python.org/issue38628.
+# XFAIL: target={{.*-aix.*}}
+
+# Hexagon has known test failures that need to be addressed.
+# https://reviews.llvm.org/D52840#1265716
+# XFAIL: target={{hexagon-.*}}
+# python SEGVs on Linux/sparc64 when loading libclang.so.  Seems to be an FFI
+# issue, too.
+# XFAIL: target={{sparc.*-.*-linux.*}}
+
+# Tests will fail if cross-compiling for a different target, as tests will try
+# to use the host Python3_EXECUTABLE and make FFI calls to functions in target
+# libraries.
+#
+# FIXME: Consider a solution that allows better control over these tests in
+# a crosscompiling scenario. e.g. registering them with lit to allow them to
+# be explicitly skipped via appropriate LIT_ARGS, or adding a mechanism to
+# allow specifying a python interpreter compiled for the target that could
+# be executed using qemu-user.
+# REQUIRES: native
+
+# SystemZ has broken Python/FFI interface
+# according to https://reviews.llvm.org/D52840#1265716
+# This leads to failures only when Clang is built with GCC apparently, see:
+# https://github.com/llvm/llvm-project/pull/146844#issuecomment-3048291798
+# REQUIRES: !target={{s390x-.*}}
+
+# RUN: env PYTHONPATH=%S/../../../bindings/python \
+# RUN:   CLANG_LIBRARY_PATH=%libdir \
+# RUN:   %python -m unittest discover -s %S/tests
diff --git a/clang/test/bindings/python/lit.local.cfg b/clang/test/bindings/python/lit.local.cfg
new file mode 100644
index 0000000000000..cc3bdf8ba97d4
--- /dev/null
+++ b/clang/test/bindings/python/lit.local.cfg
@@ -0,0 +1,41 @@
+def is_libclang_loadable():
+    # Do not try to run if libclang was built with sanitizers because
+    # the sanitizer library will likely be loaded too late to perform
+    # interception and will then fail.
+    # We could use LD_PRELOAD/DYLD_INSERT_LIBRARIES but this isn't
+    # portable so its easier just to not run the tests when building
+    # with ASan.
+    if config.llvm_use_sanitizer != "":
+        return False
+    try:
+        sys.path.append(os.path.join(config.clang_src_dir, "bindings/python"))
+        from clang.cindex import Config
+        conf = Config()
+        Config.set_library_path(config.clang_lib_dir)
+        conf.lib
+        return True
+    except Exception as e:
+        # Expected failure modes are considered benign when nothing can be
+        # done about them.
+        #
+        # Cannot load a 32-bit libclang.so into a 64-bit python.
+        if "wrong ELF class: ELFCLASS32" in str(e):
+            return False
+        # If libclang.so is missing, it must have been disabled intentionally,
+        # e.g. by building with LLVM_ENABLE_PIC=OFF.
+        elif "No such file or directory" in str(e):
+            return False
+        # Unexpected failure modes need to be investigated to either fix an
+        # underlying bug or accept the failure, so return True.  This causes
+        # tests to run and FAIL, drawing developer attention.
+        else:
+            print("warning: unhandled failure in is_libclang_loadable: "
+                  + str(e), file=sys.stderr)
+            return True
+
+if is_libclang_loadable():
+    config.available_features.add("libclang-loadable")
+
+config.substitutions.append(('%libdir', config.clang_lib_dir))
+
+config.suffixes = ['.sh']
diff --git a/clang/bindings/python/tests/__init__.py b/clang/test/bindings/python/tests/__init__.py
similarity index 100%
rename from clang/bindings/python/tests/__init__.py
rename to clang/test/bindings/python/tests/__init__.py
diff --git a/clang/bindings/python/tests/cindex/INPUTS/a.inc b/clang/test/bindings/python/tests/cindex/INPUTS/a.inc
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/a.inc
rename to clang/test/bindings/python/tests/cindex/INPUTS/a.inc
diff --git a/clang/bindings/python/tests/cindex/INPUTS/b.inc b/clang/test/bindings/python/tests/cindex/INPUTS/b.inc
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/b.inc
rename to clang/test/bindings/python/tests/cindex/INPUTS/b.inc
diff --git a/clang/bindings/python/tests/cindex/INPUTS/compile_commands.json b/clang/test/bindings/python/tests/cindex/INPUTS/compile_commands.json
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/compile_commands.json
rename to clang/test/bindings/python/tests/cindex/INPUTS/compile_commands.json
diff --git a/clang/bindings/python/tests/cindex/INPUTS/header1.h b/clang/test/bindings/python/tests/cindex/INPUTS/header1.h
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/header1.h
rename to clang/test/bindings/python/tests/cindex/INPUTS/header1.h
diff --git a/clang/bindings/python/tests/cindex/INPUTS/header2.h b/clang/test/bindings/python/tests/cindex/INPUTS/header2.h
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/header2.h
rename to clang/test/bindings/python/tests/cindex/INPUTS/header2.h
diff --git a/clang/bindings/python/tests/cindex/INPUTS/header3.h b/clang/test/bindings/python/tests/cindex/INPUTS/header3.h
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/header3.h
rename to clang/test/bindings/python/tests/cindex/INPUTS/header3.h
diff --git a/clang/bindings/python/tests/cindex/INPUTS/hello.cpp b/clang/test/bindings/python/tests/cindex/INPUTS/hello.cpp
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/hello.cpp
rename to clang/test/bindings/python/tests/cindex/INPUTS/hello.cpp
diff --git a/clang/bindings/python/tests/cindex/INPUTS/include.cpp b/clang/test/bindings/python/tests/cindex/INPUTS/include.cpp
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/include.cpp
rename to clang/test/bindings/python/tests/cindex/INPUTS/include.cpp
diff --git a/clang/bindings/python/tests/cindex/INPUTS/parse_arguments.c b/clang/test/bindings/python/tests/cindex/INPUTS/parse_arguments.c
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/parse_arguments.c
rename to clang/test/bindings/python/tests/cindex/INPUTS/parse_arguments.c
diff --git a/clang/bindings/python/tests/cindex/INPUTS/testfile.c b/clang/test/bindings/python/tests/cindex/INPUTS/testfile.c
similarity index 100%
rename from clang/bindings/python/tests/cindex/INPUTS/testfile.c
rename to clang/test/bindings/python/tests/cindex/INPUTS/testfile.c
diff --git a/clang/bindings/python/tests/cindex/__init__.py b/clang/test/bindings/python/tests/cindex/__init__.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/__init__.py
rename to clang/test/bindings/python/tests/cindex/__init__.py
diff --git a/clang/bindings/python/tests/cindex/test_access_specifiers.py b/clang/test/bindings/python/tests/cindex/test_access_specifiers.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_access_specifiers.py
rename to clang/test/bindings/python/tests/cindex/test_access_specifiers.py
diff --git a/clang/bindings/python/tests/cindex/test_cdb.py b/clang/test/bindings/python/tests/cindex/test_cdb.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_cdb.py
rename to clang/test/bindings/python/tests/cindex/test_cdb.py
diff --git a/clang/bindings/python/tests/cindex/test_code_completion.py b/clang/test/bindings/python/tests/cindex/test_code_completion.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_code_completion.py
rename to clang/test/bindings/python/tests/cindex/test_code_completion.py
diff --git a/clang/bindings/python/tests/cindex/test_comment.py b/clang/test/bindings/python/tests/cindex/test_comment.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_comment.py
rename to clang/test/bindings/python/tests/cindex/test_comment.py
diff --git a/clang/bindings/python/tests/cindex/test_cursor.py b/clang/test/bindings/python/tests/cindex/test_cursor.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_cursor.py
rename to clang/test/bindings/python/tests/cindex/test_cursor.py
diff --git a/clang/bindings/python/tests/cindex/test_cursor_kind.py b/clang/test/bindings/python/tests/cindex/test_cursor_kind.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_cursor_kind.py
rename to clang/test/bindings/python/tests/cindex/test_cursor_kind.py
diff --git a/clang/bindings/python/tests/cindex/test_diagnostics.py b/clang/test/bindings/python/tests/cindex/test_diagnostics.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_diagnostics.py
rename to clang/test/bindings/python/tests/cindex/test_diagnostics.py
diff --git a/clang/bindings/python/tests/cindex/test_enums.py b/clang/test/bindings/python/tests/cindex/test_enums.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_enums.py
rename to clang/test/bindings/python/tests/cindex/test_enums.py
diff --git a/clang/bindings/python/tests/cindex/test_exception_specification_kind.py b/clang/test/bindings/python/tests/cindex/test_exception_specification_kind.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_exception_specification_kind.py
rename to clang/test/bindings/python/tests/cindex/test_exception_specification_kind.py
diff --git a/clang/bindings/python/tests/cindex/test_file.py b/clang/test/bindings/python/tests/cindex/test_file.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_file.py
rename to clang/test/bindings/python/tests/cindex/test_file.py
diff --git a/clang/bindings/python/tests/cindex/test_index.py b/clang/test/bindings/python/tests/cindex/test_index.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_index.py
rename to clang/test/bindings/python/tests/cindex/test_index.py
diff --git a/clang/bindings/python/tests/cindex/test_lib.py b/clang/test/bindings/python/tests/cindex/test_lib.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_lib.py
rename to clang/test/bindings/python/tests/cindex/test_lib.py
diff --git a/clang/bindings/python/tests/cindex/test_linkage.py b/clang/test/bindings/python/tests/cindex/test_linkage.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_linkage.py
rename to clang/test/bindings/python/tests/cindex/test_linkage.py
diff --git a/clang/bindings/python/tests/cindex/test_location.py b/clang/test/bindings/python/tests/cindex/test_location.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_location.py
rename to clang/test/bindings/python/tests/cindex/test_location.py
diff --git a/clang/bindings/python/tests/cindex/test_rewrite.py b/clang/test/bindings/python/tests/cindex/test_rewrite.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_rewrite.py
rename to clang/test/bindings/python/tests/cindex/test_rewrite.py
diff --git a/clang/bindings/python/tests/cindex/test_source_range.py b/clang/test/bindings/python/tests/cindex/test_source_range.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_source_range.py
rename to clang/test/bindings/python/tests/cindex/test_source_range.py
diff --git a/clang/bindings/python/tests/cindex/test_tls_kind.py b/clang/test/bindings/python/tests/cindex/test_tls_kind.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_tls_kind.py
rename to clang/test/bindings/python/tests/cindex/test_tls_kind.py
diff --git a/clang/bindings/python/tests/cindex/test_token_kind.py b/clang/test/bindings/python/tests/cindex/test_token_kind.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_token_kind.py
rename to clang/test/bindings/python/tests/cindex/test_token_kind.py
diff --git a/clang/bindings/python/tests/cindex/test_tokens.py b/clang/test/bindings/python/tests/cindex/test_tokens.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_tokens.py
rename to clang/test/bindings/python/tests/cindex/test_tokens.py
diff --git a/clang/bindings/python/tests/cindex/test_translation_unit.py b/clang/test/bindings/python/tests/cindex/test_translation_unit.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_translation_unit.py
rename to clang/test/bindings/python/tests/cindex/test_translation_unit.py
diff --git a/clang/bindings/python/tests/cindex/test_type.py b/clang/test/bindings/python/tests/cindex/test_type.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/test_type.py
rename to clang/test/bindings/python/tests/cindex/test_type.py
diff --git a/clang/bindings/python/tests/cindex/util.py b/clang/test/bindings/python/tests/cindex/util.py
similarity index 100%
rename from clang/bindings/python/tests/cindex/util.py
rename to clang/test/bindings/python/tests/cindex/util.py